Ser908
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Home > Phosphorylation Site Page: > Ser908  -  LATS1 (mouse)

Site Information
HQRCLAHsLVGTPNY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457594

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 5 , 6 ) , phospho-antibody ( 1 , 2 , 4 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
lung cancer ( 2 ) , non-small cell lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 ) , fibrosarcoma of soft tissue ( 2 )
Relevant cell line - cell type - tissue:
2fTGH (fibroblast) ( 2 ) , A549 (pulmonary) ( 2 ) , brain ( 5 ) , HT1080 (fibroblast) ( 2 ) , liver ( 6 ) , lung ( 2 ) , MEF (fibroblast) ( 2 ) , MEL (erythroid) ( 1 ) , MMTV-PyMT (breast cell) ( 4 ) , mononuclear-blood ( 2 ) , spleen ( 2 )

Upstream Regulation
Regulatory protein:
IFNAR1 (human) ( 2 ) , MST1 (human) ( 2 ) , MST2 (human) ( 2 ) , SAC (human) ( 1 )
Putative in vivo kinases:
PKACA (human) ( 1 )
Treatments:
IFN-alpha ( 2 ) , IFN-beta ( 2 ) , IFN-gamma ( 2 ) , IFN-Lambda 3 ( 2 ) , IL-6 ( 2 ) , isoproterenol ( 1 ) , KT5720 ( 1 ) , LRE1 ( 1 ) , TNF ( 2 )

Downstream Regulation
Effects of modification on LATS1:
enzymatic activity, induced ( 2 ) , intracellular localization ( 2 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
cell growth, inhibited ( 2 ) , signaling pathway regulation ( 2 ) , transcription, induced ( 2 )

References 

1

Drozdz MM, et al. (2022) A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation. Cell Rep 40, 111412
36170819   Curated Info

2

Zuo Y, et al. (2022) LATS1 is a central signal transmitter for achieving full type-I interferon activity. Sci Adv 8, eabj3887
35394840   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Calvo F, et al. (2013) Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol 15, 637-46
23708000   Curated Info

5

Guo A (2011) CST Curation Set: 12477; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

6

Guo A (2011) CST Curation Set: 12478; Year: 2011; Biosample/Treatment: tissue, liver/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

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