Tyr21
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Home > Phosphorylation Site Page: > Tyr21  -  SLC4A1 (human)

Site Information
ENLEQEEyEDPDIPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457533

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 7 ) , [32P] bio-synthetic labeling ( 6 ) , mass spectrometry ( 3 , 6 ) , peptide sequencing ( 6 ) , phospho-antibody ( 1 , 2 , 5 , 6 ) , phosphoamino acid analysis ( 7 ) , phosphopeptide mapping ( 6 , 7 ) , western blotting ( 1 , 2 , 5 , 6 )
Relevant cell line - cell type - tissue:
blood ( 1 ) , erythrocyte ( 5 , 7 ) , erythrocyte-blood ( 2 , 6 )

Upstream Regulation
Putative in vivo kinases:
Syk (human) ( 6 )
Kinases, in vitro:
LYN (human) ( 4 ) , Syk (human) ( 4 , 6 )
Putative upstream phosphatases:
SHP-2 (human) ( 5 )
Phosphatases, in vitro:
SHP-1 (human) ( 4 ) , SHP-2 (human) ( 5 )
Treatments:
diamide ( 5 ) , N-ethylmaleimede ( 5 ) , PP1 ( 6 ) , vanadate ( 5 , 6 )

Downstream Regulation
Effects of modification on SLC4A1:
molecular association, regulation ( 2 , 6 )
Induce interaction with:
LYN (human) ( 6 )
Inhibit interaction with:
ANK1 (human) ( 2 )

References 

1

Wu X, et al. (2023) Tyrosine phosphorylation of band 3 impairs the storage quality of suspended red blood cells in the Tibetan high-altitude polycythemia population. J Transl Med 21, 676
37770909   Curated Info

2

Puchulu-Campanella E, Turrini FM, Li YH, Low PS (2016) Global transformation of erythrocyte properties via engagement of an SH2-like sequence in band 3. Proc Natl Acad Sci U S A 113, 13732-13737
27856737   Curated Info

3

De Franceschi L, et al. (2011) Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity. Blood 118, 5652-63
21951684   Curated Info

4

Bragadin M, Ion-Popa F, Clari G, Bordin L (2007) SHP-1 tyrosine phosphatase in human erythrocytes. Ann N Y Acad Sci 1095, 193-203
17404032   Curated Info

5

Bordin L, et al. (2002) Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes. Blood 100, 276-82
12070037   Curated Info

6

Brunati AM, et al. (2000) Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: identification of primary and secondary phosphorylation sites. Blood 96, 1550-7
10942405   Curated Info

7

Yannoukakos D, et al. (1991) Phosphorylation sites in human erythrocyte band 3 protein. Biochim Biophys Acta 1061, 253-66
1998697   Curated Info

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