Ser236
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser236  -  VASP (rat)

Site Information
GAKLRKVsKEEASGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448380

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 7 ) , phospho-antibody ( 2 , 4 , 5 , 6 , 7 ) , western blotting ( 2 , 4 , 5 , 7 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 6 ) , A7r5 ('muscle, smooth') ( 5 ) , BAEC (endothelial) ( 7 ) , cerebral artery ( 4 ) , heart ( 2 ) , microvessel endothelial ( 2 ) , vascular smooth muscle cell ('muscle, smooth') [eNOS (cow)] ( 7 ) , vessel ( 6 )

Upstream Regulation
Regulatory protein:
eNOS (human) ( 7 )
Treatments:
angiotensin_2 ( 7 ) , cGMP_analog ( 4 ) , hypoxia/reoxygenation ( 2 ) , ischemia/reperfusion ( 2 ) , L-NAME ( 4 ) , SNP ( 5 ) , streptozotocin ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
type 2 diabetes ( 6 )

References 

1

Engin S, Yasar YK, Barut EN, Sezen SF (2021) Improved Endothelium-Dependent Relaxation of Thoracic Aorta in Niclosamide-Treated Diabetic Rats. Cardiovasc Toxicol
33772737   Curated Info

2

Li L, et al. (2015) Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα. PLoS One 10, e0139570
26440524   Curated Info

3

Oelze M, et al. (2014) The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity. PLoS One 9, e112394
25402275   Curated Info

4

Neppl RL, et al. (2009) Thromboxane A2-induced bi-directional regulation of cerebral arterial tone. J Biol Chem 284, 6348-60
19095646   Curated Info

5

Zhou Z, et al. (2008) Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity. Arterioscler Thromb Vasc Biol 28, 1803-10
18635821   Curated Info

6

Blume C, et al. (2007) AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem 282, 4601-12
17082196   Curated Info

7

Suzuki H, et al. (2006) Activation of endothelial nitric oxide synthase by the angiotensin II type 1 receptor. Endocrinology 147, 5914-20
16980435   Curated Info