Ser663
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Home > Phosphorylation Site Page: > Ser663  -  NHE3 (human)

Site Information
TMRKRLEsFKSTKLG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457469
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 2 , 3 ) , non-small cell lung cancer ( 2 , 3 ) , non-small cell lung adenocarcinoma ( 2 , 3 )
Relevant cell line - cell type - tissue:
C2BBe1 (intestinal) ( 1 ) , Cal-12T (pulmonary) ( 3 ) , DMS153 (pulmonary) ( 2 ) , HCC44 (pulmonary) ( 3 ) , lung ( 2 , 3 ) , NCI-H1437 (pulmonary) ( 2 , 3 ) , NCI-H1666 (pulmonary) ( 3 ) , NCI-H2073 (pulmonary) ( 2 ) , NCI-H209 (pulmonary) ( 2 ) , NCI-H2405 (pulmonary) ( 3 ) , NCI-H838 (pulmonary) ( 2 )

Upstream Regulation
Putative in vivo kinases:
RSK2 (human) ( 1 )

Downstream Regulation
Effects of modification on NHE3:
intracellular localization ( 1 )

References 

1

No YR, He P, Yoo BK, Yun CC (2015) Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2. Am J Physiol Cell Physiol 309, C14-21
25855080   Curated Info

2

Rikova K, Hall B (2013) CST Curation Set: 20742, 21169, 30176, 30177, 30178; Year: 2013; Biosample/Treatment: cell line, H838, DMS153, H2073, H209, H1437; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

3

Rikova K, Hall B (2013) CST Curation Set: 20741, 21168, 30173, 30174, 30175; Year: 2013; Biosample/Treatment: cell line, H1666, CAL-12T, H2405, HCC44, H1437; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

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