Ser663
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Home > Phosphorylation Site Page: > Ser663  -  NHE3 (rabbit)

Site Information
TMRKRLEsFKSAKLG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457469

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKG2 (human) ( 1 )
Kinases, in vitro:
SGK1 (human) ( 2 )
Treatments:
cGMP_analog ( 1 ) , dexamethasone ( 1 , 2 )

Downstream Regulation
Effects of modification on NHE3:
activity, induced ( 1 , 2 ) , activity, inhibited ( 1 ) , intracellular localization ( 1 , 2 )

References 

1

Chen T, et al. (2015) Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site. J Biol Chem 290, 1952-65
25480791   Curated Info

2

Wang D, Sun H, Lang F, Yun CC (2005) Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1. Am J Physiol Cell Physiol 289, C802-10
15888551   Curated Info