Ser607
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Home > Phosphorylation Site Page: > Ser607  -  NHE3 (rabbit)

Site Information
SLEQRRRsVRDAEDV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450900

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
ileum ( 1 ) , PS120 (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKG2 (human) ( 1 )
Kinases, in vitro:
PKG2 (human) ( 1 )
Treatments:
cGMP_analog ( 1 ) , NKH_477 ( 1 )

Downstream Regulation
Effects of modification on NHE3:
activity, inhibited ( 1 ) , intracellular localization ( 1 )

References 

1

Chen T, et al. (2015) Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site. J Biol Chem 290, 1952-65
25480791   Curated Info