Tyr442

Site Information
KILEEVRyIANRFRC SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 457467

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Disease tissue studied:	leukemia ( 2 ) , acute lymphocytic leukemia ( 2 )
Relevant cell line - cell type - tissue:	SEM (B lymphocyte) ( 2 )

Upstream Regulation
Kinases, in vitro:	Src (human) ( 1 )

Downstream Regulation
Effects of modification on nAChRA7:	activity, inhibited ( 1 )

References
1	Charpantier E, et al. (2005) Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases. J Neurosci 25, 9836-49 16251431 Curated Info
2	Gu T (2005) CST Curation Set: 514; Year: 2005; Biosample/Treatment: cell line, SEM/-; Disease: acute lymphocytic leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info

References

Charpantier E, et al. (2005) Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases. J Neurosci 25, 9836-49
16251431 Curated Info

Gu T (2005) CST Curation Set: 514; Year: 2005; Biosample/Treatment: cell line, SEM/-; Disease: acute lymphocytic leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info