Tyr327
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Home > Phosphorylation Site Page: > Tyr327  -  SLAM (human)

Site Information
ETNSITVyASVTLPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447634

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 )

Upstream Regulation
Putative in vivo kinases:
Fyn (human) ( 2 ) , LYN (human) ( 1 )
Kinases, in vitro:
LYN (human) ( 1 )
Treatments:
anti-CD150 ( 1 ) , anti-CD3 ( 2 )

Downstream Regulation
Effects of modification on SLAM:
molecular association, regulation ( 1 , 2 )
Induce interaction with:
APCS (human) ( 2 ) , SH2D1A (human) ( 1 ) , SHP-2 (human) ( 1 , 2 )

References 

1

Mikhalap SV, et al. (2004) The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. Blood 104, 4063-70
15315965   Curated Info

2

Howie D, et al. (2002) Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Blood 99, 957-65
11806999   Curated Info

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