Ser411
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Home > Phosphorylation Site Page: > Ser411  -  ADRB2 (human)

Site Information
RNCstNDsLL_____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457444

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 , 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 , 4 )

Upstream Regulation
Putative in vivo kinases:
GRK2 (human) ( 2 )
Kinases, in vitro:
GRK5 (human) ( 5 )

Downstream Regulation
Effects of modification on ADRB2:
molecular association, regulation ( 4 )
Inhibit interaction with:
NHERF (human) ( 4 )

References 

1

Gimenez LE, et al. (2012) Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors. J Biol Chem 287, 9028-40
22275358   Curated Info

2

Nobles KN, et al. (2011) Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal 4, ra51
21868357   Curated Info

3

Krasel C, et al. (2008) Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization. J Biol Chem 283, 31840-8
18801735   Curated Info

4

Cao TT, et al. (1999) A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature 401, 286-90
10499588   Curated Info

5

Fredericks ZL, Pitcher JA, Lefkowitz RJ (1996) Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. J Biol Chem 271, 13796-803
8662852   Curated Info