Ser411

Site Information
RNCstNDsLL_____ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 457444

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 2 , 3 , 4 ) , COS7 (fibroblast) ( 1 )

Downstream Regulation
Effects of modification on ADRB2:	molecular association, regulation ( 4 ) , protein conformation ( 2 )
Inhibit interaction with:	NHERF (human) ( 4 )

References
1	Gimenez LE, et al. (2012) Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors. J Biol Chem 287, 9028-40 22275358 Curated Info
2	Nobles KN, et al. (2011) Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal 4, ra51 21868357 Curated Info
3	Krasel C, et al. (2008) Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization. J Biol Chem 283, 31840-8 18801735 Curated Info
4	Cao TT, et al. (1999) A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature 401, 286-90 10499588 Curated Info
5	Fredericks ZL, Pitcher JA, Lefkowitz RJ (1996) Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. J Biol Chem 271, 13796-803 8662852 Curated Info