Ser91
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Home > Phosphorylation Site Page: > Ser91  -  p21Cip1 (dog)

Site Information
TCTLLPHsPERPEAS   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4943330

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
Cf2Th (thymocyte) ( 2 ) , MDCK (epithelial) ( 2 )

Upstream Regulation
Putative upstream phosphatases:
PPM1D (human) ( 1 )
Phosphatases, in vitro:
PPM1D (human) ( 1 )
Treatments:
CCT007093 ( 1 )

Downstream Regulation
Effects of modification on p21Cip1:
protein stabilization ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )

References 

1

Cao R, Zhang J, Zhang M, Chen X (2015) PPM1D regulates p21 expression via dephoshporylation at serine 123. Cell Cycle 14, 641-7
25590690   Curated Info

2

Chen X, et al. (2012) Serine 123 Phosphorylation Modulates p21 Protein Stability and Activity by Suppressing Ubiquitin-independent Proteasomal Degradation. J Biol Chem 287, 34410-8
22908227   Curated Info