Ser42
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Home > Phosphorylation Site Page: > Ser42  -  NFL (mouse)

Site Information
TARsAYSsysAPVss   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457402

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Disease tissue studied:
adrenal cancer ( 1 )
Relevant cell line - cell type - tissue:
brain ( 2 ) , neuron ( 1 ) , SF9 ( 1 ) , SW13 (adrenal) ( 1 )

Upstream Regulation
Treatments:
KT5720 ( 1 ) , NKH_477 ( 1 )

Downstream Regulation
Effects of modification on NFL:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
14-3-3 gamma (mouse) ( 1 )

References 

1

Miao L, et al. (2013) 14-3-3 proteins interact with neurofilament protein-L and regulate dynamic assembly of neurofilaments. J Cell Sci 126, 427-36
23230147   Curated Info

2

Zhou J (2009) CST Curation Set: 7375; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: YXp[ST]
Curated Info