Ser667
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Home > Phosphorylation Site Page: > Ser667  -  SCN5A (human)

Site Information
QRALsAVsVLtsALE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25752820

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 )

Upstream Regulation
Kinases, in vitro:
CAMK2A (human) ( 2 )
Treatments:
TAC ( 1 )

Downstream Regulation
Effects of modification on SCN5A:
activity, induced ( 1 ) , protein conformation ( 1 )

References 

1

Lorenzini M, et al. (2021) Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites. J Gen Physiol 153
33410863   Curated Info

2

Herren AW, et al. (2015) CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. J Proteome Res 14, 2298-311
25815641   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

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