Thr118

Site Information
GERPARLtrGEADRD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 25752435

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 ) , mass spectrometry (in vitro) ( 4 )
Disease tissue studied:	acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 3 ) , acute megakaryoblastic leukemia (M7) ( 3 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 3 ) , acute myeloblastic leukemia, with granulocytic maturation (M2) ( 3 ) , acute myeloblastic leukemia, without maturation (M1) ( 3 ) , B cell lymphoma ( 3 ) , non-Hodgkin's lymphoma ( 3 ) , multiple myeloma ( 3 )
Relevant cell line - cell type - tissue:	AML-193 (monocyte) ( 3 ) , CMK (megakaryoblast) ( 3 ) , CTS (myeloid) ( 3 ) , DOHH2 ('B lymphocyte, precursor') ( 3 ) , HEL (erythroid) ( 3 ) , HeLa (cervical) ( 2 ) , K562 (erythroid) ( 2 ) , Kasumi-1 (myeloid) ( 3 ) , KG-1 (myeloid) ( 3 ) , MV4-11 (macrophage) ( 3 ) , OPM-2 (plasma cell) ( 3 ) , P31/FUJ (erythroid) ( 3 ) , RL ('B lymphocyte, precursor') ( 3 ) , RPMI-8266 (plasma cell) ( 3 ) , SU-DHL-6 (B lymphocyte) ( 3 ) , U266 (plasma cell) ( 3 )

Upstream Regulation
Kinases, in vitro:	AurB (human) ( 4 )

References
1	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
2	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
3	Casado P, et al. (2013) Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol 14, R37 23628362 Curated Info
4	Hengeveld RC, et al. (2012) Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex. Mol Cell Proteomics 11, 47-59 22267324 Curated Info