Tyr335
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Home > Phosphorylation Site Page: > Tyr335  -  IRF5 (human)

Site Information
QLQGQDLyAIRLCQC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25742049

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
dendritic cell ( 1 )

Upstream Regulation
Putative in vivo kinases:
LYN (human) ( 1 )

Downstream Regulation
Effects of modification on IRF5:
molecular association, regulation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )
Induce interaction with:
LYN (human) ( 1 )

References 

1

Ban T, et al. (2016) Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45, 319-32
27521268   Curated Info

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