Ser384
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Home > Phosphorylation Site Page: > Ser384  -  GLUD1 (human)

Site Information
DILIPAAsEkQLTkS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25739562

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioblastoma multiforme ( 1 ) , glioma ( 1 ) , melanoma skin cancer ( 3 )
Relevant cell line - cell type - tissue:
liver ( 4 ) , LN18 (glial) ( 1 ) , U-251 MG (glial) ( 1 ) , U87MG (glial) ( 1 ) , WM239A (melanocyte) ( 3 )

Upstream Regulation
Regulatory protein:
AMPKA1 (human) ( 1 )
Treatments:
compound_C ( 1 ) , low_glucose ( 1 ) , LY294002 ( 1 ) , MK-2206 ( 1 ) , rapamycin ( 1 ) , SP600125 ( 1 )

Downstream Regulation
Effects of modification on GLUD1:
activity, induced ( 1 ) , enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
IKKB (human) ( 1 ) , NFkB-p65 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
glioblastoma multiforme ( 1 )

References 

1

Wang X, et al. (2019) α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development. Mol Cell
31447391   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

4

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

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