Ser60
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Home > Phosphorylation Site Page: > Ser60  -  PPP2R5D (human)

Site Information
PsSNKRPsNstPPPt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457388

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HCT116 (intestinal) ( 1 ) , HeLa (cervical) ( 1 ) , oocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
Chk1 (human) ( 1 )
Kinases, in vitro:
Chk1 (human) ( 1 ) , PKACA (human) ( 2 )

Downstream Regulation
Effects of modification on PPP2R5D:
molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )
Induce interaction with:
PPP2CA (human) ( 1 )

References 

1

Margolis SS, et al. (2006) Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell 127, 759-73
17110335   Curated Info

2

Usui H, et al. (1998) Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B'' (delta) regulatory subunit in vitro and identification of the phosphorylation sites. FEBS Lett 430, 312-6
9688562   Curated Info

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