Ser12

Site Information
EEsQsDIsLELPLsQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 447538

In vivo Characterization
Methods used to characterize site in vivo:	2D analysis ( 1 ) , [32P] bio-synthetic labeling ( 1 ) , immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 2 ) , phosphopeptide mapping ( 1 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:	3T3 (fibroblast) ( 2 ) , COS (fibroblast) ( 1 ) , SV3T3 (fibroblast) ( 1 )

References
1	Knippschild U, et al. (1997) p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene 15, 1727-36 9349507 Curated Info
2	Hao M, et al. (1996) Mutation of phosphoserine 389 affects p53 function in vivo. J Biol Chem 271, 29380-5 8910602 Curated Info
3	Milne DM, Palmer RH, Campbell DG, Meek DW (1992) Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme. Oncogene 7, 1361-9 1620549 Curated Info