Ser1042

Ser1042

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Home > Phosphorylation Site Page: > Ser1042 - ITGA3 (human)

Site Information
AEMkSQPsEtERLtD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 447602

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 10 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 8 , 9 , 10 ) , mutation of modification site ( 10 )
Disease tissue studied:	breast cancer ( 3 , 6 ) , lung cancer ( 4 , 6 ) , non-small cell lung cancer ( 6 ) , non-small cell lung adenocarcinoma ( 4 ) , ovarian cancer ( 2 )
Relevant cell line - cell type - tissue:	A549 (pulmonary) ( 5 ) , BT-549 (breast cell) ( 6 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 10 ) , H2009 (pulmonary) ( 6 ) , H2887 (pulmonary) ( 6 ) , HCC1359 (pulmonary) ( 6 ) , HCC1937 (breast cell) ( 6 ) , HCC2279 (pulmonary) ( 6 ) , HCC366 (pulmonary) ( 6 ) , HCC4006 (pulmonary) ( 6 ) , HCC78 (pulmonary) ( 6 ) , HCC827 (pulmonary) ( 6 ) , HeLa (cervical) ( 8 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 3 ) , HMLER ('stem, breast cancer') ( 3 ) , HOP62 (pulmonary) ( 6 ) , K562 (erythroid) ( 10 ) , LCLC-103H (pulmonary) ( 6 ) , LOU-NH91 (squamous) ( 6 ) , lung ( 4 ) , MCF-7 (breast cell) ( 6 ) , MDA-MB-231 (breast cell) ( 6 ) , NCI-H2172 (pulmonary) ( 6 ) , NCI-H322 (pulmonary) ( 6 ) , NCI-H460 (pulmonary) ( 6 ) , ovary ( 2 ) , TERT20 ('stem, mesenchymal') ( 9 ) , Vero E6-S ('epithelial, kidney') ( 1 )

Upstream Regulation
Treatments:	phorbol_ester ( 10 )

Downstream Regulation
Effects of modification on ITGA3:	intracellular localization ( 10 ) , molecular association, regulation ( 10 )
Effects of modification on biological processes:	cell adhesion, altered ( 10 ) , cytoskeletal reorganization ( 10 )

References
1	Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell 32645325 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90 24782546 Curated Info
4	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
5	Kim JY, et al. (2013) Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells. Proc Natl Acad Sci U S A 110, 12414-9 23836654 Curated Info
6	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
7	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
8	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
9	Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313 18578522 Curated Info
10	Zhang XA, et al. (2001) Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement. Mol Biol Cell 12, 351-65 11179420 Curated Info

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