Lys72
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Home > Ubiquitylation Site Page: > Lys72  -  TAK1 (human)

Site Information
IESESERkAFIVELR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25698801

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
MG132 ( 1 ) , TNF ( 1 )

Downstream Regulation
Effects of modification on TAK1:
protein degradation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Fan Y, et al. (2012) Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFα-induced NF-κB activation via mediating TAK1 degradation. Cell Signal 24, 1381-9
22406003   Curated Info