Ser54
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Home > Phosphorylation Site Page: > Ser54  -  SHC1 (human)

Site Information
PPLPGDDsPTTLCSF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457345

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) [SHC1 (human)] ( 1 ) , PC-12 (chromaffin) ( 1 )

Upstream Regulation
Kinases, in vitro:
P38A (human) ( 1 )
Treatments:
SB203580 ( 1 )

Downstream Regulation
Effects of modification on SHC1:
protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )

References 

1

Khanday FA, et al. (2006) Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress. Mol Biol Cell 17, 122-9
16251354   Curated Info