Ser92
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser92  -  Snail2 (human)

Site Information
RVsPPPPsDTSsKDH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25603910

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 2 ) , lung cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , CL1-5 (pulmonary) ( 1 ) , MCF-7 (breast cell) ( 2 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 , 2 )
Kinases, in vitro:
GSK3B (human) ( 1 )

Downstream Regulation
Effects of modification on Snail2:
intracellular localization ( 2 ) , protein degradation ( 1 , 2 )
Effects of modification on biological processes:
cell motility, inhibited ( 1 ) , transcription, induced ( 1 , 2 )
Induce interaction with:
CHIP (human) ( 1 )

References 

1

Kao SH, et al. (2014) GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene 33, 3172-82
23851495   Curated Info

2

Kim JY, et al. (2012) Functional regulation of Slug / Snail2 is dependent on GSK-3β-mediated phosphorylation. FEBS J 279, 2929-39
22727060   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.