Ser104
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Home > Phosphorylation Site Page: > Ser104  -  Snail2 (human)

Site Information
KDHsGSEsPISDEEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25603909

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , immunoprecipitation ( 1 , 3 ) , mass spectrometry ( 1 , 3 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
bone cancer ( 2 ) , breast cancer ( 1 , 4 ) , lung cancer ( 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , CL1-5 (pulmonary) ( 2 , 3 ) , MCF-7 (breast cell) ( 4 ) , MDA-MB-231 (breast cell) ( 1 ) , U2OS (bone cell) ( 2 )

Upstream Regulation
Putative in vivo kinases:
CDK2 (human) ( 2 ) , GSK3B (human) ( 3 , 4 )
Kinases, in vitro:
CDK2 (human) ( 2 ) , ERK2 (human) ( 1 ) , GSK3B (human) ( 3 )
Treatments:
CHEMBL267048 ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on Snail2:
protein degradation ( 2 , 3 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , cell motility, inhibited ( 3 ) , transcription, induced ( 3 )
Induce interaction with:
CHIP (human) ( 3 )

References 

1

Virtakoivu R, et al. (2015) Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function. Cancer Res 75, 2349-62
25855378   Curated Info

2

Wang WL, et al. (2015) Slug is temporally regulated by cyclin E in cell cycle and controls genome stability. Oncogene 34, 1116-25
24662826   Curated Info

3

Kao SH, et al. (2014) GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene 33, 3172-82
23851495   Curated Info

4

Kim JY, et al. (2012) Functional regulation of Slug / Snail2 is dependent on GSK-3β-mediated phosphorylation. FEBS J 279, 2929-39
22727060   Curated Info

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