Ser459
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Home > Phosphorylation Site Page: > Ser459  -  PTPN3 (human)

Site Information
QKSsSSVsPSSNAPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25594501

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
Caco-2 (intestinal) ( 2 ) , HCT116 (intestinal) ( 2 ) , HEK293T (epithelial) ( 1 , 2 ) , HT-29 (intestinal) ( 2 ) , IEC-6 (epithelial) ( 2 ) , Ls174T (intestinal) ( 2 ) , MEF (fibroblast) ( 2 ) , SKCO1 (epithelial) ( 2 ) , SW480 (intestinal) ( 2 ) , T84 (intestinal) ( 2 )

Upstream Regulation
Putative in vivo kinases:
P38G (human) ( 2 )
Kinases, in vitro:
P38G (human) ( 2 )
Treatments:
arsenite ( 2 ) , EGF ( 2 ) , MKK6DD ( 2 ) , phorbol_ester ( 2 ) , pirfenidone ( 2 ) , SB203580 ( 2 ) , siRNA ( 2 ) , sorbitol ( 2 )

Downstream Regulation
Effects of modification on PTPN3:
enzymatic activity, induced ( 1 ) , protein stabilization ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , carcinogenesis, induced ( 2 ) , cell growth, induced ( 2 )

References 

1

Ma S, et al. (2015) Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER). Oncotarget 6, 13320-33
26079946   Curated Info

2

Hou S, et al. (2012) p38γ Mitogen-activated Protein Kinase Signals through Phosphorylating Its Phosphatase PTPH1 in Regulating Ras Protein Oncogenesis and Stress Response. J Biol Chem 287, 27895-905
22730326   Curated Info

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