Thr344
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Home > Phosphorylation Site Page: > Thr344  -  SIRT1 (human)

Site Information
GkLLRNYtQNIDTLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25594500

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 )
Kinases, in vitro:
AurA (human) ( 1 )

Downstream Regulation
Effects of modification on SIRT1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , cytoskeletal reorganization ( 1 )
Induce interaction with:
PLK2 (human) ( 1 )
Inhibit interaction with:
DBC-1 (human) ( 1 )

References 

1

Ling H, et al. (2018) Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication. Cell Rep 25, 2851-2865.e3
30517871   Curated Info

2

Lau AW, Liu P, Inuzuka H, Gao D (2014) SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. Am J Cancer Res 4, 245-55
24959379   Curated Info

3

Lee CW, et al. (2012) AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells. Cancer Res 72, 4394-404
22728651   Curated Info