Ser87

Site Information
SSSLGRVsPPPPsDT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 25525400

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Disease tissue studied:	breast cancer ( 1 , 3 ) , melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:	MCF-7 (breast cell) ( 3 ) , MDA-MB-231 (breast cell) ( 1 ) , WM239A (melanocyte) ( 2 )

Downstream Regulation
Effects of modification on biological processes:	cell motility, induced ( 1 ) , transcription, induced ( 1 )

References
1	Virtakoivu R, et al. (2015) Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function. Cancer Res 75, 2349-62 25855378 Curated Info
2	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
3	Kim JY, et al. (2012) Functional regulation of Slug / Snail2 is dependent on GSK-3β-mediated phosphorylation. FEBS J 279, 2929-39 22727060 Curated Info