Ser1834
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Home > Phosphorylation Site Page: > Ser1834  -  p300 (human)

Site Information
MLRRRMAsMQRTGVV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447591

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 ) , modification-specific antibody ( 1 , 2 ) , mutation of modification site ( 3 , 4 , 5 , 6 ) , phospho-antibody ( 1 , 2 , 3 , 5 , 6 ) , western blotting ( 1 , 2 , 3 , 5 )
Disease tissue studied:
gastric cancer ( 2 ) , gastric carcinoma ( 2 ) , lung cancer ( 1 , 5 , 6 ) , non-small cell lung cancer ( 1 , 5 ) , non-small cell lung adenocarcinoma ( 1 ) , non-small cell large cell lung carcinoma ( 5 )
Relevant cell line - cell type - tissue:
A431 (epithelial) ( 4 ) , A549 (pulmonary) ( 1 , 6 ) , HEK293T (epithelial) ( 5 ) , N87 (gastric) ( 2 ) , NCI-H358 (pulmonary) ( 5 ) , NCI-H460 (pulmonary) ( 5 ) , NHF (fibroblast) ( 3 )

Upstream Regulation
Regulatory protein:
Akt1 (human) ( 1 ) , p70S6K (human) ( 1 )
Putative in vivo kinases:
Akt1 (human) ( 3 , 5 , 6 )
Kinases, in vitro:
Akt1 (human) ( 5 , 6 , 7 )
Treatments:
light ( 2 ) , LY294002 ( 2 , 3 , 5 , 6 ) , rapamycin ( 1 ) , SB203580 ( 3 ) , SH-5 ( 6 ) , siRNA ( 1 , 5 ) , thrombin ( 1 ) , TNF ( 6 ) , UV ( 3 ) , vorinostat ( 5 )

Downstream Regulation
Effects of modification on p300:
molecular association, regulation ( 6 )
Effects of modification on biological processes:
transcription, induced ( 5 , 6 )
Induce interaction with:
CAF-1A (human) ( 6 )

References 

1

Lin CH, et al. (2020) Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells. Eur J Pharmacol 868, 172879
31863766   Curated Info

2

Fahey JM, Korytowski W, Girotti AW (2019) Upstream signaling events leading to elevated production of pro-survival nitric oxide in photodynamically-challenged glioblastoma cells. Free Radic Biol Med 137, 37-45
30991141   Curated Info

3

Wang QE, et al. (2013) p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair. Nucleic Acids Res 41, 1722-33
23275565   Curated Info

4

Chen YJ, Wang YN, Chang WC (2007) ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression. J Biol Chem 282, 27215-28
17623675   Curated Info

5

Liu Y, et al. (2006) Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65. J Biol Chem 281, 31359-68
16926151   Curated Info

6

Huang WC, Chen CC (2005) Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. Mol Cell Biol 25, 6592-602
16024795   Curated Info

7

Guo S, et al. (2001) Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta. J Biol Chem 276, 8516-23
11116148   Curated Info

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