Lys129
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Home > Acetylation Site Page: > Lys129  -  Survivin (human)

Site Information
kEFEETAkkVRRAIE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25558401

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on Survivin:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
STAT3 (human) ( 1 ) , Survivin (human) ( 1 )
Inhibit interaction with:
Exportin-1 (human) ( 1 )

References 

1

Wang H, et al. (2010) Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. J Biol Chem 285, 36129-37
20826784   Curated Info