Ser65
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Home > Phosphorylation Site Page: > Ser65  -  PARK2 (mouse)

Site Information
NCDLEQQsIVHIVQR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25538008

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 5 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
'brain, cerebrum' ( 4 ) , 'brain, hippocampus' ( 1 ) , endothelial ( 2 ) , heart ( 3 ) , MEF (fibroblast) ( 5 )

Upstream Regulation
Regulatory protein:
GAS7 (human) ( 4 )
Putative in vivo kinases:
PINK1 (human) ( 2 )
Treatments:
GW_9662 ( 1 ) , ligustrazine piperazine derivative ( 1 ) , Mdivi-1 ( 1 ) , pitavastatin ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on PARK2:
activity, induced ( 3 )
Effects of modification on biological processes:
autophagy, induced ( 1 , 2 ) , cell growth, induced ( 2 )

References 

1

Li Z, et al. (2022) Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARĪ³-dependent enhancement of mitophagy in APP/PS1 mice. Alzheimers Res Ther 14, 150
36217155   Curated Info

2

Yang J, et al. (2022) Pitavastatin activates mitophagy to protect EPC proliferation through a calcium-dependent CAMK1-PINK1 pathway in atherosclerotic mice. Commun Biol 5, 124
35145192   Curated Info

3

Kim M, et al. (2022) Evaluation of Parkin in the Regulation of Myocardial Mitochondria-Associated Membranes and Cardiomyopathy During Endotoxemia. Front Cell Dev Biol 10, 796061
35265609   Curated Info

4

Bhupana JN, et al. (2020) Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons. FASEB Bioadv
32161906   Curated Info

5

Lee SB, et al. (2019) The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome. Nat Cell Biol 21, 940-951
31358971   Curated Info

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