Thr224
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.7
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr224  -  DVL2 (human)

Site Information
MSRFssStEQSsASR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25538000

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HeLa (cervical) ( 2 )

Upstream Regulation
Regulatory protein:
Daple (human) ( 1 )
Putative in vivo kinases:
CK1D (human) ( 1 , 2 ) , CK1E (human) ( 1 , 2 )
Kinases, in vitro:
CK1D (human) ( 2 ) , CK1E (human) ( 2 )
Treatments:
BI2536 ( 2 ) , BMI-1026 ( 2 ) , GSK-3_inhibitor_X ( 2 ) , IC261 ( 1 , 2 ) , siRNA ( 2 ) , VX-680 ( 2 ) , Wnt3a ( 1 ) , Wnt5a ( 2 )

Downstream Regulation
Effects of modification on DVL2:
intracellular localization ( 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 ) , transcription, induced ( 1 )
Induce interaction with:
PLK1 (human) ( 2 )

References 

1

Esaki N, et al. (2020) The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling. Biochem Biophys Res Commun
32888647   Curated Info

2

Lee KH, et al. (2012) Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J 31, 3104-17
22609948   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.