Ser138
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Home > Phosphorylation Site Page: > Ser138  -  PIN1 (human)

Site Information
QkPFEDAsFALrTGE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25519816

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 2 ) , luminal A breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , 3T3 (fibroblast) ( 2 ) , breast ( 1 , 2 ) , HeLa (cervical) ( 2 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Putative in vivo kinases:
MLK3 (human) ( 2 )
Kinases, in vitro:
MLK3 (human) ( 2 )

Downstream Regulation
Effects of modification on PIN1:
intracellular localization ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Rangasamy V, et al. (2012) Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proc Natl Acad Sci U S A 109, 8149-54
22566623   Curated Info