Lys277
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Home > Sumoylation Site Page: > Lys277  -  GR (human)

Site Information
NVtLPQVkTEkEDFI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2532301

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 4 , 5 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 2 , 3 ) , modification-specific antibody ( 4 , 5 ) , mutation of modification site ( 4 ) , western blotting ( 4 , 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
dexamethasone ( 4 )

Downstream Regulation
Effects of modification on GR:
protein degradation ( 5 )
Effects of modification on biological processes:
transcription, induced ( 5 ) , transcription, inhibited ( 4 )

References 

1

Lumpkin RJ, et al. (2017) Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun 8, 1171
29079793   Curated Info

2

Hendriks IA, et al. (2014) Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol 21, 927-36
25218447   Curated Info

3

Tammsalu T, et al. (2014) Proteome-wide identification of SUMO2 modification sites. Sci Signal 7, rs2
24782567   Curated Info

4

Tian S, Poukka H, Palvimo JJ, Jänne OA (2002) Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor. Biochem J 367, 907-11
12144530   Curated Info

5

Le Drean Y, Mincheneau N, Le Goff P, Michel D (2002) Potentiation of glucocorticoid receptor transcriptional activity by sumoylation. Endocrinology 143, 3482-9
12193561   Curated Info