Lys293
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Home > Sumoylation Site Page: > Lys293  -  GR (human)

Site Information
LCtPGVIkQEkLGTV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2532300

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 5 , 6 ) , immunoprecipitation ( 5 ) , mass spectrometry ( 3 ) , modification-specific antibody ( 5 , 6 ) , mutation of modification site ( 2 , 5 ) , western blotting ( 5 , 6 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
dexamethasone ( 5 )

Downstream Regulation
Effects of modification on GR:
protein degradation ( 6 )
Effects of modification on biological processes:
transcription, induced ( 6 ) , transcription, inhibited ( 2 , 5 )

References 

1

Lumpkin RJ, et al. (2017) Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun 8, 1171
29079793   Curated Info

2

Hua G, Ganti KP, Chambon P (2016) Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex. Proc Natl Acad Sci U S A 113, E635-43
26712006   Curated Info

3

Hendriks IA, et al. (2014) Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol 21, 927-36
25218447   Curated Info

4

Impens F, Radoshevich L, Cossart P, Ribet D (2014) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc Natl Acad Sci U S A 111, 12432-7
25114211   Curated Info

5

Tian S, Poukka H, Palvimo JJ, Jänne OA (2002) Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor. Biochem J 367, 907-11
12144530   Curated Info

6

Le Drean Y, Mincheneau N, Le Goff P, Michel D (2002) Potentiation of glucocorticoid receptor transcriptional activity by sumoylation. Endocrinology 143, 3482-9
12193561   Curated Info