Ser153

Site Information
ktVANLLsGksPRKs SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2526064

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 3 , 4 , 6 , 7 , 8 , 9 , 10 , 11 , 12 )
Disease tissue studied:	HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 ) , leukemia ( 8 ) , acute myelogenous leukemia ( 8 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 6 ) , acute megakaryoblastic leukemia (M7) ( 6 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 6 ) , acute myeloblastic leukemia, with granulocytic maturation (M2) ( 6 ) , acute myeloblastic leukemia, without maturation (M1) ( 6 ) , lung cancer ( 7 ) , non-small cell lung cancer ( 7 ) , B cell lymphoma ( 6 ) , non-Hodgkin's lymphoma ( 6 ) , multiple myeloma ( 6 )
Relevant cell line - cell type - tissue:	AML-193 (monocyte) ( 6 ) , breast ( 1 ) , Calu 6 (pulmonary) ( 7 ) , CMK (megakaryoblast) ( 6 ) , CTS (myeloid) ( 6 ) , DOHH2 ('B lymphocyte, precursor') ( 6 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 9 ) , Flp-In T-Rex-293 (epithelial) ( 9 ) , H2009 (pulmonary) ( 7 ) , H2077 (pulmonary) ( 7 ) , H2887 (pulmonary) ( 7 ) , H322M (pulmonary) ( 7 ) , HCC1359 (pulmonary) ( 7 ) , HCC2279 (pulmonary) ( 7 ) , HCC4006 (pulmonary) ( 7 ) , HEL (erythroid) ( 6 ) , HeLa (cervical) ( 3 , 10 , 11 , 12 ) , HOP62 (pulmonary) ( 7 ) , Jurkat (T lymphocyte) ( 4 ) , Kasumi-1 (myeloid) ( 6 ) , KG-1 (myeloid) ( 6 ) , MV4-11 (macrophage) ( 6 , 8 ) , NCI-H1568 (pulmonary) ( 7 ) , NCI-H1648 (pulmonary) ( 7 ) , NCI-H2172 (pulmonary) ( 7 ) , NCI-H322 (pulmonary) ( 7 ) , NCI-H647 (pulmonary) ( 7 ) , OPM-2 (plasma cell) ( 6 ) , P31/FUJ (erythroid) ( 6 , 8 ) , RL ('B lymphocyte, precursor') ( 6 ) , RPMI-8266 (plasma cell) ( 6 ) , SU-DHL-6 (B lymphocyte) ( 6 ) , U266 (plasma cell) ( 6 )

Upstream Regulation
Treatments:	PI-103 ( 8 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610 27184836 Curated Info
3	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
4	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
5	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
6	Casado P, et al. (2013) Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol 14, R37 23628362 Curated Info
7	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
8	Alcolea MP, et al. (2012) Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. Mol Cell Proteomics 11, 453-66 22547687 Curated Info
9	Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70 22496350 Curated Info
10	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
11	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info
12	Imami K, et al. (2008) Automated Phosphoproteome Analysis for Cultured Cancer Cells by Two-Dimensional NanoLC-MS Using a Calcined Titania/C18 Biphasic Column. Anal Sci 24, 161-6 18187866 Curated Info