Thr243
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Home > Phosphorylation Site Page: > Thr243  -  PGK1 (human)

Site Information
IGGGMAFtFLKVLNN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2525475

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , multiple myeloma ( 1 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
IL1B (human) ( 1 )
Putative in vivo kinases:
PDK1 (human) ( 1 )
Kinases, in vitro:
PDK1 (human) ( 1 )
Treatments:
CoCL2 ( 1 ) , coculture ( 1 ) , EGF ( 1 ) , IL-6 ( 1 ) , M-CSF ( 1 ) , OSU-03012 ( 1 ) , siRNA ( 1 ) , TGF-beta ( 1 )

Downstream Regulation
Effects of modification on PGK1:
enzymatic activity, altered ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )
Induce interaction with:
PDK1 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
glioblastoma multiforme ( 1 )

References 

1

Zhang Y, et al. (2018) Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis. Mol Cell 71, 201-215.e7
30029001   Curated Info

2

Imami K, et al. (2008) Automated Phosphoproteome Analysis for Cultured Cancer Cells by Two-Dimensional NanoLC-MS Using a Calcined Titania/C18 Biphasic Column. Anal Sci 24, 161-6
18187866   Curated Info