Thr594

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Home > Phosphorylation Site Page: > Thr594 - SCN5A (human)

Site Information
LHGkKNStVDCNGVV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 25244201

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 )

Upstream Regulation
Kinases, in vitro:	CAMK2D (human) ( 1 ) , CAMK2D (rat) ( 1 )

Downstream Regulation
Effects of modification on SCN5A:	activity, inhibited ( 1 )

References
1	Ashpole NM, et al. (2012) Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel NaV1.5 Gating by Multiple Phosphorylation Sites. J Biol Chem 287, 19856-69 22514276 Curated Info

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