Ser315
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Home > Phosphorylation Site Page: > Ser315  -  COL4A3BP (human)

Site Information
DYEEGPNsLINEEEF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25174303

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 3 ) , mass spectrometry ( 2 , 4 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
cervical cancer ( 3 ) , cervical adenocarcinoma ( 3 ) , leukemia ( 4 ) , acute myelogenous leukemia ( 4 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 , 2 ) , HeLa S3 (cervical) ( 3 ) , KG-1 (myeloid) ( 4 )

Upstream Regulation
Treatments:
hypertonic_buffer ( 1 ) , myriocin ( 1 , 3 ) , osmotic_stress ( 1 ) , sorbitol ( 1 ) , sphingomyelinase ( 3 )

Downstream Regulation
Effects of modification on COL4A3BP:
activity, induced ( 1 ) , intracellular localization ( 3 ) , molecular association, regulation ( 1 , 3 )
Effects of modification on biological processes:
chromatin organization, altered ( 3 )
Induce interaction with:
VAPA (human) ( 1 , 3 )

References 

1

Shimasaki K, et al. (2022) Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum. Int J Mol Sci 23
35409383   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Kumagai K, Kawano-Kawada M, Hanada K (2014) Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells. J Biol Chem 289, 10748-60
24569996   Curated Info

4

Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56
22115753   Curated Info

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