Ser1229

Site Information
AMBIGUOUS SITES: Abl (human):
LDHEPAVsPLLPRKE SwissProt
Blast this site against: NCBI SwissProt PDB
Site Group ID: 25172818

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 5 )
Disease tissue studied:	breast cancer ( 4 ) , lung cancer ( 4 ) , non-small cell lung cancer ( 4 ) , melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:	BT-20 (breast cell) ( 4 ) , BT-549 (breast cell) ( 4 ) , Calu 6 (pulmonary) ( 4 ) , H2009 (pulmonary) ( 4 ) , H2077 (pulmonary) ( 4 ) , H2887 (pulmonary) ( 4 ) , H322M (pulmonary) ( 4 ) , HCC1937 (breast cell) ( 4 ) , HCC2279 (pulmonary) ( 4 ) , HCC366 (pulmonary) ( 4 ) , HCC78 (pulmonary) ( 4 ) , HOP62 (pulmonary) ( 4 ) , HUES-9 ('stem, embryonic') ( 5 ) , MCF-7 (breast cell) ( 4 ) , MDA-MB-231 (breast cell) ( 4 ) , MDA-MB-468 (breast cell) ( 4 ) , NCI-H157 (pulmonary) ( 4 ) , NCI-H1648 (pulmonary) ( 4 ) , NCI-H1666 (pulmonary) ( 4 ) , NCI-H2172 (pulmonary) ( 4 ) , NCI-H322 (pulmonary) ( 4 ) , NCI-H520 (squamous) ( 4 ) , PC9 (pulmonary) ( 4 ) , SH-SY5Y (neural crest) [LRRK2 (human), transfection, over-expression of LRRK2(G2019S)] ( 3 ) , WM239A (melanocyte) ( 2 )

Upstream Regulation
Treatments:	LRRK2-IN-1 ( 3 )

References
1	Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610 27184836 Curated Info
2	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
3	Luerman GC, et al. (2014) Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. J Neurochem 128, 561-76 24117733 Curated Info
4	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
5	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info