Lys10
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Home > Acetylation Site Page: > Lys10  -  HIF1A (human)

Site Information
GAGGANDkkkISSER   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25126718

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:
293T (epithelial) ( 1 ) , A2780 (ovarian) ( 1 ) , ES2 (ovarian) ( 1 ) , SKOV-3 (ovarian) ( 1 )

Downstream Regulation
Effects of modification on HIF1A:
protein degradation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Zhang Y, et al. (2017) Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis. Oncogene 36, 4171-4181
28319066   Curated Info

2

Geng H, et al. (2011) HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia. J Biol Chem 286, 38095-102
21917920   Curated Info