Lys11
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Acetylation Site Page: > Lys11  -  HIF1A (human)

Site Information
AGGANDkkkISSERR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25126715

In vivo Characterization
Methods used to characterize site in vivo:
modification-specific antibody ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , A2780 (ovarian) ( 1 ) , ES2 (ovarian) ( 1 ) , HEK293T (epithelial) ( 1 , 2 ) , Hep3B (hepatic) ( 2 ) , SKOV-3 (ovarian) ( 1 )

Upstream Regulation
Treatments:
siRNA ( 2 ) , vorinostat ( 2 )

Downstream Regulation
Effects of modification on HIF1A:
protein degradation ( 1 , 2 )
Effects of modification on biological processes:
transcription, inhibited ( 1 , 2 )

References 

1

Zhang Y, et al. (2017) Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis. Oncogene 36, 4171-4181
28319066   Curated Info

2

Geng H, et al. (2011) HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia. J Biol Chem 286, 38095-102
21917920   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.