Ser181
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Home > Phosphorylation Site Page: > Ser181  -  SOX9 (mouse)

Site Information
YQPrrrKsVKNGQAE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456981

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , mutation of modification site ( 5 ) , phospho-antibody ( 3 , 5 , 6 ) , western blotting ( 5 )
Disease tissue studied:
testicular cancer ( 5 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 5 ) , chondrocyte-embryo ( 6 ) , embryonic ( 3 ) , endothelial ( 3 ) , gonad ( 5 ) , heart ( 3 ) , NT2 (testicular) ( 5 ) , RCS (chondrocyte) ( 6 )

Upstream Regulation
Regulatory protein:
ROCK1 (human) ( 3 )
Treatments:
differentiation ( 5 )

Downstream Regulation
Effects of modification on SOX9:
intracellular localization ( 3 )
Effects of modification on biological processes:
transcription, induced ( 3 )

References 

1

Guo D, et al. (2021) Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. J Exp Med 218
34254999   Curated Info

2

Al-Zahrani KN, et al. (2021) AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer. Breast Cancer Res 23, 55
33985544   Curated Info

3

Gallina D, Lincoln J (2019) Dynamic Expression Profiles of Sox9 in Embryonic, Post Natal, and Adult Heart Valve Cell Populations. Anat Rec (Hoboken) 302, 108-116
30412364   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Malki S, et al. (2005) Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. EMBO J 24, 1798-809
15889150   Curated Info

6

Huang W, Zhou X, Lefebvre V, de Crombrugghe B (2000) Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol 20, 4149-58
10805756   Curated Info