Ser246
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Home > Phosphorylation Site Page: > Ser246  -  ERF (human)

Site Information
RGGPEPLsPFPVsPL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456967

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 2 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 2 ) , REF (fibroblast) ( 1 ) , Saos-2 (bone cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK2 (human) ( 2 )
Kinases, in vitro:
ERK2 (human) ( 2 )
Treatments:
EGF ( 1 ) , PD98059 ( 2 ) , serum ( 1 , 2 )

Downstream Regulation
Effects of modification on ERF:
intracellular localization ( 1 , 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 , 2 )

References 

1

Le Gallic L, et al. (2004) ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression. Mol Cell Biol 24, 1206-18
14729966   Curated Info

2

Le Gallic L, Sgouras D, Beal G, Mavrothalassitis G (1999) Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation. Mol Cell Biol 19, 4121-33
10330152   Curated Info

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