Ser78
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Home > Phosphorylation Site Page: > Ser78  -  BID (mouse)

Site Information
RIEPDSEsQEEIIHN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456957

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 6 ) , mass spectrometry ( 1 , 2 , 4 ) , mutation of modification site ( 2 , 6 ) , phospho-antibody ( 2 , 3 , 5 , 6 ) , western blotting ( 2 , 3 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 1 , 4 ) , 293 (epithelial) ( 2 ) , DLD1 (intestinal) ( 2 ) , HeLa (cervical) ( 3 , 6 ) , MEF (fibroblast) [IGF1R (mouse)] ( 5 ) , MEF (fibroblast) ( 2 ) , RKO (intestinal) ( 2 )

Upstream Regulation
Regulatory protein:
ALPI (human) ( 2 )
Treatments:
aphidicolin ( 5 ) , etoposide ( 2 , 3 , 5 , 6 ) , granzyme_B ( 3 ) , hydroxyurea ( 5 ) , ionizing_radiation ( 5 , 6 ) , mitomycin_C ( 5 ) , perforin ( 3 ) , UV ( 5 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , apoptosis, inhibited ( 6 ) , cell cycle regulation ( 2 , 5 , 6 )

References 

1

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

2

Wang P, et al. (2014) Phosphorylation of the proapoptotic BH3-only protein bid primes mitochondria for apoptosis during mitotic arrest. Cell Rep 7, 661-71
24767991   Curated Info

3

Brasacchio D, et al. (2014) A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage. Cell Death Differ 21, 748-60
24464226   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Zinkel SS, et al. (2005) A role for proapoptotic BID in the DNA-damage response. Cell 122, 579-91
16122425   Curated Info

6

Kamer I, et al. (2005) Proapoptotic BID is an ATM effector in the DNA-damage response. Cell 122, 593-603
16122426   Curated Info

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