Thr122

Site Information
LTACQLRtIYICQFL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2481000

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:	breast cancer ( 2 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 1 ) , MCF-7 (breast cell) ( 2 )

Downstream Regulation
Effects of modification on TRF1:	intracellular localization ( 2 ) , molecular association, regulation ( 2 ) , protein stabilization ( 1 , 2 )
Induce interaction with:	CK2B (human) ( 2 ) , DNA ( 1 , 2 ) , TRF1 (human) ( 2 )

References
1	Yoo JE, Park YN, Oh BK (2014) PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. J Biol Chem 289, 6886-98 24415760 Curated Info
2	Kim MK, et al. (2008) Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation. J Biol Chem 283, 14144-52 18347021 Curated Info