Ser219
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Home > Phosphorylation Site Page: > Ser219  -  ROMK (rat)

Site Information
RVANLRKsLLIGSHI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2461201

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
oocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Treatments:
colforsin ( 2 ) , gabapentin ( 1 ) , H-89 ( 1 ) , IBMX ( 2 ) , KT5720 ( 1 )

Downstream Regulation
Effects of modification on ROMK:
activity, induced ( 1 ) , protein conformation ( 1 )

References 

1

Lee CH, Tsai TS, Liou HH (2008) Gabapentin activates ROMK1 channels by a protein kinase A (PKA)-dependent mechanism. Br J Pharmacol 154, 216-25
18311184   Curated Info

2

Xu ZC, Yang Y, Hebert SC (1996) Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase. J Biol Chem 271, 9313-9
8621594   Curated Info