Thr663
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Home > Phosphorylation Site Page: > Thr663  -  ENaC-alpha (human)

Site Information
SAGASSStCPLGGP_   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456847

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
oocyte ( 2 )

Upstream Regulation
Regulatory protein:
CK1D (human) ( 1 )
Treatments:
calphostin_C ( 2 ) , IC261 ( 1 ) , phorbol_ester ( 2 )

Downstream Regulation
Effects of modification on ENaC-alpha:
intracellular localization ( 1 )

References 

1

Yan W, et al. (2007) Intracellular trafficking of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel is modulated by casein kinase 1. Am J Physiol Renal Physiol 293, F868-76
17596527   Curated Info

2

Yan W, Suaud L, Kleyman TR, Rubenstein RC (2006) Differential modulation of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel by protein kinase Cdelta. Am J Physiol Renal Physiol 290, F279-88
16174865   Curated Info

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