Ser588
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser588  -  APS (rat)

Site Information
SARSRSNsTEHLLEA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456846

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 )
Kinases, in vitro:
Akt1 (human) ( 1 )
Treatments:
deguelin ( 1 ) , insulin ( 1 ) , LY294002 ( 1 )

Downstream Regulation
Effects of modification on APS:
intracellular localization ( 1 )

References 

1

Katsanakis KD, Pillay TS (2005) Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. J Biol Chem 280, 37827-32
16141217   Curated Info