Tyr88
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Home > Phosphorylation Site Page: > Tyr88  -  p27Kip1 (mouse)

Site Information
RGsLPEFyYRPPRPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456818

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
JAK2 (mouse) ( 2 )
Kinases, in vitro:
JAK2 (mouse) ( 2 )
Treatments:
angiotensin_2 ( 1 ) , IL-3 ( 2 ) , JAK_inhibitor_I ( 2 ) , SKI-606 ( 1 )

Downstream Regulation
Effects of modification on p27Kip1:
molecular association, regulation ( 1 )
Inhibit interaction with:
CK2A1 (human) ( 1 )

References 

1

Kashihara T, et al. (2017) Angiotensin II activates CaV 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes. J Physiol 595, 4207-4225
28295363   Curated Info

2

Jäkel H, Weinl C, Hengst L (2011) Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. Oncogene 30, 3502-12
21423214   Curated Info