Ser212
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Home > Phosphorylation Site Page: > Ser212  -  MARK2 (rat)

Site Information
KLDtFCGsPPYAAPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450068

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 4 ) , peptide sequencing ( 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
F11 (neuron) ( 2 ) , Neuro-2a (neuron) ( 1 )

Upstream Regulation
Kinases, in vitro:
GSK3B (human) ( 2 )
Treatments:
Nogo ( 1 )

Downstream Regulation
Effects of modification on MARK2:
enzymatic activity, induced ( 2 , 4 ) , enzymatic activity, inhibited ( 3 )

References 

1

Zuo YC, et al. (2016) MARK2 Rescues Nogo-66-Induced Inhibition of Neurite Outgrowth via Regulating Microtubule-Associated Proteins in Neurons In Vitro. Neurochem Res 41, 2958-2968
27465397   Curated Info

2

Kosuga S, et al. (2005) GSK-3beta directly phosphorylates and activates MARK2/PAR-1. J Biol Chem 280, 42715-22
16257959   Curated Info

3

Timm T, et al. (2003) MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 22, 5090-101
14517247   Curated Info

4

Drewes G, et al. (1997) MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89, 297-308
9108484   Curated Info