Ser505
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Home > Phosphorylation Site Page: > Ser505  -  PDZK1 (human)

Site Information
MAKERAHstAsHsss   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456807

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , MKN-45 (gastric) ( 2 ) , S.cerevisiae ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Treatments:
cicaprost ( 1 ) , Go_6983 ( 1 ) , H-89 ( 1 ) , KT5720 ( 1 ) , R01138452 ( 1 )

Downstream Regulation
Effects of modification on PDZK1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , cell motility, induced ( 1 )
Induce interaction with:
PTGIR (human) ( 1 )

References 

1

Turner EC, Mulvaney EP, Reid HM, Kinsella BT (2011) Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis. Mol Biol Cell 22, 2664-79
21653824   Curated Info

2

Rush J (2008) CST Curation Set: 4491; Year: 2008; Biosample/Treatment: cell line, MKN-45/untreated &'||' normal; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info