Tyr959
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Home > Phosphorylation Site Page: > Tyr959  -  TRPC4 (human)

Site Information
EEDssIDyDLNLPDT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456713

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
EGFR (human) ( 3 )
Treatments:
EGF ( 3 )

Downstream Regulation
Effects of modification on TRPC4:
activity, induced ( 2 , 3 ) , intracellular localization ( 3 )
Induce interaction with:
NHERF (human) ( 3 )

References 

1

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

2

Jung C, et al. (2011) A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction. Cardiovasc Res 91, 465-71
21427121   Curated Info

3

Odell AF, Scott JL, Van Helden DF (2005) Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4. J Biol Chem 280, 37974-87
16144838   Curated Info